2012
IWISH 2012 Proceeding
Volatile organic compounds in exhaled breath: real-time measurements, modeling, and bio-monitoring applications
Authors: Julian King, Karl Unterkofler, Susanne Teschl, Anton Amann, Gerald Teschl
Abstract
The present paper reviews some paradigmatic applications of modeling and simulation in the context of exhaled breath analysis, which has emerged as a promising tool for collecting non-invasive and continuous information on the metabolic and physiological state of an individual. In particular, it is illustrated how real-time breath profiles of volatile organic compounds (as obtained, e.g., by PTR-(TOF)- MS) can be used to extract in vivo estimates of endogenous quantities that are difficult to access by conventional analytical approaches based on blood, urine, or tissue. Typical examples include the determination of production and metabolism rates, as well as tracking the tissue accumulation of exogenously administered trace gases (e.g., volatile anesthetics).
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