2012
IWISH 2012 Proceeding
Investigation of the effect of drugs on solid tumours within a systems-based mathematical modelling framework
Authors: Cong Liu, J. Krishnan, Xiao Yun Xu
Abstract
The study develops a skeletal modeling framework to systematically evaluate the effect of anticancer drugs on solid tumors, especially from the perspective of cellular signaling. The modeling framework incorporates interstitial drug transport, intracellular apoptosis signaling and the dynamics of tumor cell density, which are regarded as the essentially minimal elements. The study deliberately starts with coarse grained descriptions of the cellular signaling, which nevertheless are capable of correctly capturing the qualitative dynamics involved. A series of simulations have been performed to provide mechanistic and predictive insights into cellular response towards different forms of drug stimuli. It is found qualitatively different intracellular signaling models can give rise to similar tissue behavior. Within the context, validating the models must be performed with care by considering a variety of drug stimuli.
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