2012
IWISH 2012 Proceeding
Uncertainty quantification for cerebral perfusion
Authors: Rachael Gordon-Wright, Pierre Gremaud, Esther Martens, Vera Novak
Abstract
There is a pressing need for noninvasive and continuous measurements of cerebral blood flow (CBF) in several areas of medicine. Transcranial Doppler (TCD) technology is clinically used for measurements of blood flow velocities (BFV). It is assumed that perfusion and vasoreactivity in a vascular territory can be inferred from BFV measurements in the corresponding stem artery. However, only very modest correlations have been found between TCD-based and magnetic resonance imaging (MRI)-based CBF measurements. Several factors, whose values are uncertain, such as vessel diameter, hematocrit and insonation angle, affect the BFV - CBF relationship. Their influence on CBF and vasoreactivity estimates has not been rigorously analyzed but cannot be ignored. We present initial work toward a subject specific computational and experimental model to both quantify and reduce the uncertainty attached to CBF and vasoreactivity estimates based on Doppler ultrasound.
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