2012
IWISH 2012 Proceeding
Baroreflex sensitivity during the gravitational stimulus: physiology and pathophysiology
Authors: Raffaello Furlan, Franca Dipaola, Veronica Pacetti, Carlo Selmi, Francesca Meda, Ilaria Bianchi, Franca Barbic
Abstract
Baroreceptor mechanisms play a crucial role in healthy humans during a gravitational stimulus to maintain blood pressure and cerebral perfusion by providing proper orthostatic tolerance. In addition, they concur to synchronize central neural discharge activity and hemodynamic spontaneous fluctuations leading to an optimal interaction between the cardiovascular neural regulatory activity and the heart and vessel response. In pathophysiological conditions as encountered before tilt induced neurally-mediated syncope, the gain of baroreflex control of heart rate and muscle sympathetic nerve activity (MSNA) is remarkably impaired, revealing a diminished capability to adapt in response to similar changes of blood pressure compared to healthy subjects. The loss of an organized post-ganglionic sympathetic discharge activity to the vessel leads to orthostatic intolerance in subjects with baroreceptor failure.
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