2012
IWISH 2012 Proceeding
A kalman filtering based approach for the modeling of the cardiovascular regulation system
Authors: Brett Matzuka, Jesper Mehlsen, Mette Olufsen, Hien Tran, Nakeya Williams
Abstract
Short-term cardiovascular responses to orthostatic stress involve complex interactions among various mechanisms of short-term cardiovascular and respiratory blood flow and blood pressure control. Clinical procedures such as sit-to-stand and head-up-tilt (HUT) are often used to assess a patient?s ability to regulate blood pressure. In this paper, we present a cardiovascular regulation model capable of predicting blood flow, volumes, and pressures in the systemic circulation during HUT. The cardiovascular regulation model adjusts cardiac contractility, vascular resistance and arterial compliance in response to changes in blood pressure. In previous studies, these control variables were modeled using a piecewise linear function parameterization. In this paper, we present an on-line estimation procedure based on the ensemble transform Kalman filter (ETKF) to estimate these dynamic control variables.
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